At home I am aggressively using the Google
Toolbar and Spybot on
XP Sp1 workstations and Spybot and
Sp2 features on XP workstations with SP2. My home workstations are pretty clean
so far and I tend to run automated daily scans on my workstations.

It is incredible how fast workstations at work get hit by Malware.
A couple of simple steps with things even as simple as the Google
Toolbar really cut down on the number of issues that we see.